General Cell Lines and Cell Cultures
Biolegend TotalSeqTM-B0439 anti-mouse CD
TotalSeq™-B0439 anti-mouse CD201 (EPCR) [RCR-16]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: PG; Size: 10 μg
ABclonal Technology GNRHR Rabbit pAb
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.
Eurofins Discoverx cAMP Hunter CHO-K1 SCTR Gs Cell Line, 2 vials. (95-0075C2)
The cAMP Hunter SCTR Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. secretin) based activation of SCTR GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type SCTR, a naturally Gs coupled GPCR. Upon activation of SCTR, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Electron Microscopy Sciences Disposable Micro Tissue, 0.75 ml
The disposable micro tissue grinder allows for homogenized tissue micro samples without cross contamination. This unit is especially useful for radioactive samples. No washing is needed; just disposed the set after use. Mortar Size: 10 x 44 mm. Pestle Size: 7 mm sphere. Made from Autocalvable Wheaton 33 low extractable borosilicate glass.
Eurofins Discoverx PathHunter CHO-K1 HRH2 β-Arrestin Cell Line, 2 vials. (93-0208C2)
The PathHunter HRH2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. histamine) based activation of HRH2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HRH2 and EA-tagged β-Arrestin-2. Activation of HRH2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ABclonal Technology CCKAR Rabbit pAb
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine.
Eurofins Discoverx PathHunter CHO-K1 mADORA2B β-Arrestin Cell Line, 2 vials. (93-0469C2)
The PathHunter mADORA2B cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. NECA) based activation of mADORA2B GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mADORA2B and EA-tagged β-Arrestin-2. Activation of mADORA2B stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Paraffin Tissue Section - Human Gallbladder Tumor: Adenocarcinoma, Well Differentiated, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx PathHunter Jurkat CTLA4 Signaling Assay, 2 vials. (93-1094C19)
The PathHunter CTLA4 Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. CD86) based activation of CTLA4 receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged CTLA4 target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/checkpoint.
IPHASE PHARMA SERVICES LLC Plateable C57BL/6 Mouse Hepatocytes,Male,5million
Primary Hepatocytes are isolated from human and animal liver tissues. It's a tool for cytochrome P450 induction, Hepatotoxicity assays and siRNA devlivery, Transfection, Sandwitch model, 3D Primary Hepatocyte Spheroid Model (Three-Dimensional Liver Culture system) and organoids culture. IPHASE provides both suspension and plateable Hepatocytes, animal or human and speical species includes: cat(feline), Guinea pig, BALB/c Nude, Ferret, Gerbil customize hepatocytes. Plateable Hepatocytes need to be used in conjunction with Thaw medium, Plateable medium, Maintenance medium and Collagen Coated Plate.These products require shipment in LN2 container therefore customer need to return the container.
Eurofins Discoverx ChemiScreen GLP-2 Receptor Stable Cell Line, 2 vials. (HTS164C)
The ChemiScreen GLP-2 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. GLP-2) based activation of GLP2R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GLP2R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of GLP2R, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ABclonal Technology NPSR1 Rabbit pAb
This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants.
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Ductus Deferens, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Medchemexpress LLC GIPR protein, mouse (HEK293, His-tag) | 50UG
Recombinant extracellular domain of mouse glucose-dependent insulinotropic polypeptide receptor (GIPR) expressed in HEK293 cells and supplied with a C-terminal 10xHis tag. The product is 116 amino acids (E19-Q134), supplied lyophilized with lot-specific formulation; predicted molecular weight is 14.7 kDa and observed as ~19-33 kDa due to glycosylation. Endotoxin level is <1 EU/μg and recommended uses include binding assays and antibody validation.
- Recombinant mouse GIPR extracellular domain, HEK293 expressed.
- C-terminal 10xHis tag for purification and detection.
- 116 amino acids (E19-Q134).
- Predicted MW 14.7 kDa; observed ~19-33 kDa due to glycosylation.
- Lyophilized with lot-specific buffer; COA lists exact formulation.
- Endotoxin level <1 EU/μg.
- Suitable for ELISA, antibody validation, and binding studies.